Investigation of Gene Polymorphisms of Vaspin, Visfatin and Chemerin in Diabetic Obese and Non-Diabetic Obese Patients.

Diabetes mellitus and obesity are very similar in terms of pathogenesis pathophysiology. Most obese patients have adipose tissue dysfunction caused by genetic environmental factors. Adipose is the source adipokines secreted from adipocytes. Vaspin, Visfatin Chemerin discovered recent years. The study consists 43 non-diabetic 51 diabetic individuals. PCR-RFLP method agarose gel electrophoresis techniques were used to detect gene polymorphisms rs17173608, Vaspin rs2236242 rs2110385 DNA samples. In our study, when patient groups examined polymorphism, statistically significant results obtained (22% → 7%, p=0.048, respectively). distribution or variants not different (p>0.05). Our indicate that rs17173608 risk factors for development diabetes individuals, however, polymorphism may be a contributory